|
| Status |
Public on Mar 31, 2019 |
| Title |
WNT signalling activity on epiblast cells (RNA-seq analysis) |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
The impact of WNT signalling activity on the acquisition and restriction of lineage propensity of germ layer progenitors and the gene network activity for cell fate decision during the development of the embryonic head was modelled in the epiblast stem cells derived and maintained under different signalling conditions. Our findings showed that the modulation of WNT activity is critical for the specification of the anterior (head) tissue progenitors in the multipotent early epiblast and the repression of WNT activity enhances the ectoderm lineage potency of the epiblast cells and poises the activation of endogenous WNT activity that drives neurogenesis during head morphogenesis.
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| |
|
| Overall design |
4 different lines with 2 or 3 replicates each.
|
| |
|
| Contributor(s) |
Osteil P, Tam PP |
| Citation missing |
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| |
| Submission date |
Jul 27, 2018 |
| Last update date |
Apr 02, 2019 |
| Contact name |
PIERRE OSTEIL |
| E-mail(s) |
posteil@cmri.org.au
|
| Phone |
412012956
|
| Organization name |
CMRI
|
| Department |
Embryology
|
| Lab |
Tam's lab
|
| Street address |
214 Hawkesbury Road
|
| City |
WESTMEAD |
| State/province |
NSW |
| ZIP/Postal code |
2145 |
| Country |
Australia |
| |
|
| Platforms (1) |
| GPL21103 |
Illumina HiSeq 4000 (Mus musculus) |
|
| Samples (9)
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| This SubSeries is part of SuperSeries: |
| GSE103369 |
WNT signalling activity on epiblast cells |
|
| Relations |
| BioProject |
PRJNA483114 |
| SRA |
SRP155466 |
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