|
| Status |
Public on Jul 01, 2019 |
| Title |
Low cytosolic folate cycling is a hallmark of U251 glioblastoma cells reprogramming towards pluripotency [RNA-seq] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
we report that U251 glioblastoma tumor spheres exhibit low cytosolic folate cycle and a reprogrammmed mitochondrial folate cycle that is presumably oriented towards oxidizing the formyl group to CO2 with the production of TetraHydroFolate and release of NADPH instead of synthesizing formate
|
| |
|
| Overall design |
RNA-Seq comparing tumor spheres and adherent monolayer cells derived from U251 glioblastoma cell line
|
| |
|
| Contributor(s) |
Zgheib R, Battaglia S, Hergalant S, Chéry C, Gauchotte G, Guéant J, Namour F |
| Citation(s) |
31395852 |
| |
| Submission date |
Jul 23, 2018 |
| Last update date |
Aug 21, 2019 |
| Contact name |
Sebastien Hergalant |
| Organization name |
INSERM
|
| Department |
Bioinformatics
|
| Lab |
NGERE
|
| Street address |
Faculté de Médecine. 9 avenue de la forêt de Haye
|
| City |
Vandoeuvre-lès-Nancy |
| ZIP/Postal code |
54505 |
| Country |
France |
| |
|
| Platforms (1) |
| GPL15433 |
Illumina HiSeq 1000 (Homo sapiens) |
|
| Samples (6)
|
| GSM3302834 |
U251 tumor spheres biological replicate 1 |
| GSM3302835 |
U251 tumor spheres biological replicate 2 |
| GSM3302836 |
U251 tumor spheres biological replicate 3 |
| GSM3302837 |
U251 monolayer cells biological replicate 1- control |
| GSM3302838 |
U251 monolayer cells biological replicate 2- control |
| GSM3302839 |
U251 monolayer cells biological replicate 3- control |
|
| This SubSeries is part of SuperSeries: |
| GSE117544 |
Low cytosolic folate cycling is a hallmark of U251 glioblastoma cells reprogramming towards pluripotency |
|
| Relations |
| BioProject |
PRJNA482432 |
| SRA |
SRP154920 |
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