|
| Status |
Public on Sep 20, 2018 |
| Title |
Single cell RNA sequencing reveals microglia-like cells in cerebrospinal fluid during virologically suppressed HIV |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Using single cell RNA sequencing (scRNA-seq) on cerebrospinal fluid (CSF) and blood from adults with HIV, we identified a rare (<5% of cells) subset of myeloid cells that are found only in CSF and that present a gene expression signature that overlaps significantly with neurodegenerative disease associated microglia
|
| |
|
| Overall design |
examination of CSF and blood for human study volunteers, prepared via SeqWell
|
| |
|
| Contributor(s) |
Mehta S, Farhadian S |
| Citation(s) |
30232286 |
| |
| Submission date |
Jul 19, 2018 |
| Last update date |
Mar 27, 2019 |
| Contact name |
Shelli Farhadian |
| E-mail(s) |
shelli.farhadian@yale.edu
|
| Phone |
9175726946
|
| Organization name |
Yale University School of Medicine
|
| Lab |
Spudich
|
| Street address |
135 College St
|
| City |
New Haven |
| State/province |
CT |
| ZIP/Postal code |
06511 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
|
| Samples (7)
|
|
| Relations |
| BioProject |
PRJNA481990 |
| SRA |
SRP154473 |
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