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Series GSE117238 Query DataSets for GSE117238
Status Public on Jul 18, 2018
Title Transcriptome profiling identified a 3-lncRNA regulatory network in transthyretin against glucose induced hRECs dysfunction
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Transcriptome of human retinal endothelial cells (hRECs) treated with low glucose (LG), high glucose (HG) or high glucose with 4 uM TTR (HG+TTR) were conducted. Differentially expressed lncRNAs, mRNAs and TTR related lncRNAs and mRNA were acquired for further analysis. Functional annotation and enrichment including KEGG pathway, GO and GSEA were applied to analyze TTR regulated pathway and process. WGCNA analysis was implemented to obtain hub modules and genes. LncRNA-mRNA regulatory network were constructed based on cis, trans and ceRNA acting mode.
Overall design Examination of Human retinal endothelial cells (hRECs) treated with low glucose (LG), high glucose (HG), or high glucose with 4 uM TTR (HG+TTR)
Contributor(s) Shao J, Yao Y
Citation(s) 31615521
Submission date Jul 17, 2018
Last update date Oct 29, 2019
Contact name Yunbin Zhang
Organization name Chinese Academy of Sciences
Department Shanghai Institute of Biochemistry and Cell Biology
Street address No. 320, Yueyang Road, Xuhui District
City Shanghai
ZIP/Postal code 200031
Country China
Platforms (1)
GPL21290 Illumina HiSeq 3000 (Homo sapiens)
Samples (9)
GSM3289431 ditang1
GSM3289432 ditang2
GSM3289433 ditang12
BioProject PRJNA481517
SRA SRP154189

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Supplementary file Size Download File type/resource
GSE117238_transcript_sample_FPKM_lncRNA.txt.gz 219.5 Kb (ftp)(http) TXT
GSE117238_transcript_sample_FPKM_mRNA.txt.gz 3.7 Mb (ftp)(http) TXT
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Processed data are available on Series record

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