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| Status |
Public on Jun 11, 2019 |
| Title |
Dissecting the autonomy of the liver circadian clock |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
The mammalian circadian clock system is made up of individual cell and tissue clocks that function as a coherent network, however it remains unclear which rhythmic functions of the liver clock are autonomous or rely on clocks in other tissues. Here, using mice which only have a functioning liver clock, we investigate the autonomous vs non-autonomous reatures of the liver clock and diurnal rhythmicity in the liver
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| Overall design |
8-12 week-old, female WT, KO and Liver-RE BMAL1-stop-FL mice (see referenced paper for details) were fed ad libitum normal chow under 12hr light/ 12hr dark schedule. Livers were harvested every 4 hours over the circadian cycle at ZT0, 4, 8, 12, 16, 20 (n=3 per time point per group). Total RNA was extracted and used for RNA-seq.
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| Contributor(s) |
Koronowski K, Kinouchi K, Welz P, Zinna V, Samad M, Chen S, Baldi P, Benitah S, Sassone-Corsi P |
| Citation(s) |
31150621, 34036284 |
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| Submission date |
Jul 16, 2018 |
| Last update date |
Jun 03, 2021 |
| Contact name |
Siwei Chen |
| E-mail(s) |
siweic@uci.edu
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| Organization name |
University of California, Irvine
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| Department |
Computer Science
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| Lab |
Pierre Baldi
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| Street address |
66304 Verano Road South
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| City |
irvine |
| State/province |
CA |
| ZIP/Postal code |
92617 |
| Country |
USA |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (54)
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| Relations |
| BioProject |
PRJNA481257 |
| SRA |
SRP153814 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE117134_casava_gene_expression.tsv.gz |
3.2 Mb |
(ftp)(http) |
TSV |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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