|
| Status |
Public on Aug 11, 2019 |
| Title |
Pleiotropic impact of DNA-PK in cancer and implications to therapeutic strategies |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
DNA-dependent protein kinase catalitic subunit (DNA-PK) is associated with aggressive disease. DNA-PK plays a role in transcriptional regulation of cancer-relevent pathways but it is not well understood. This study uses transcriptomic analyses to understand the transcriptional role of DNA-PK in castration resistent prostate cancer (CRPC) upon DNA-PK inhibition
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| |
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| Overall design |
Transcriptional alterations upon DNA-PK inhibition were assessed through RNA-Seq of C4-2 prostate cancer cells
Transcriptional alterations upon DNA-PK inhibition were assessed through RNA-Seq of 22RV1 prostate cancer cells
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| |
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| Contributor(s) |
Knudsen KE, Dylgjeri E |
| Citation(s) |
31266833 |
| |
| Submission date |
Jul 08, 2018 |
| Last update date |
Aug 11, 2019 |
| Contact name |
Emanuela Dylgjeri |
| E-mail(s) |
emanuela.dylgjeri@jefferson.edu
|
| Organization name |
Thomas Jefferson University
|
| Department |
Cancer Biology
|
| Lab |
Karen Knudsen
|
| Street address |
233 S 10th St
|
| City |
Philadelphia |
| State/province |
Pennsylvania |
| ZIP/Postal code |
19107 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
|
| Samples (29)
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|
| Relations |
| BioProject |
PRJNA480169 |
| SRA |
SRP152787 |
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