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| Status |
Public on Nov 30, 2018 |
| Title |
Human NK cells under normoxic and hypoxic conditions |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Hypoxia, which characterizes most tumor tissues, can alter the function of different immune cell types, favoring tumor escape mechanisms. In this study, we show that hypoxia profoundly acts on NK cells by influencing their transcriptome, affecting their immunoregulatory functions, and changing the chemiotactic responses of different NK cell subsets.
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| Overall design |
The transcriptome of fresh isolated human NK cells cultured under normoxia and hypoxia was studied.
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| Contributor(s) |
Parodi M, Raggi F, Cangelosi D, Manzini C, Balsamo M, Blengio F, Eva A, Varesio L, Pietra G, Moretta L, Mingari MC, Vitale M, Bosco MC |
| Citation(s) |
30459756 |
| |
| Submission date |
Jul 05, 2018 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Davide Cangelosi |
| E-mail(s) |
davide.cangelosi@gmail.com
|
| Organization name |
IRCCS Istituto Giannina Gaslini
|
| Lab |
Laboratory of Molecular Biology
|
| Street address |
Via Gerolamo Gaslini 5
|
| City |
Genova |
| ZIP/Postal code |
16147 |
| Country |
Italy |
| |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (12)
|
| GSM3244962 |
403_16h_N: NK cells from donor 1 treated under normoxia for 16H |
| GSM3244963 |
403_16h_H: NK cells from donor 1 treated under hypoxia for 16H |
| GSM3244964 |
780_16h_N: NK cells from donor 2 treated under normoxia for 16H |
| GSM3244965 |
780_16h_H: NK cells from donor 2 treated under hypoxia for 16H |
| GSM3244966 |
3010_16h_N: NK cells from donor 3 treated under normoxia for 16H |
| GSM3244967 |
3010_16h_H: NK cells from donor 3 treated under hypoxia for 16H |
| GSM3244968 |
643_96h_N: NK cells from donor 1 treated under normoxia for 96H |
| GSM3244969 |
643_96h_H: NK cells from donor 1 treated under hypoxia for 96H |
| GSM3244970 |
1461_96h_N: NK cells from donor 2 treated under normoxia for 96H |
| GSM3244971 |
1461_96h_H: NK cells from donor 2 treated under hypoxia for 96H |
| GSM3244972 |
2339_96h_N: NK cells from donor 3 treated under normoxia for 96H |
| GSM3244973 |
2339_96h_H: NK cells from donor 3 treated under hypoxia for 96H |
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| Relations |
| BioProject |
PRJNA479833 |
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