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Series GSE116619 Query DataSets for GSE116619
Status Public on Jan 27, 2022
Title Phase 1 Trial With Challenge to Assess the Safety and Biomarkers of Protection in Malaria-naive Adults of Immunization Via Mosquito Bite With Radiation-Attenuated Plasmodium Falciparum Sporozoites (IMRAS) - Day 0-28
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary This study is to assess the safety, tolerability, and biomarkers of protection in healthy malaria-naive adults, who will receive bites from Anopheles stephensi mosquitoes either infected with Plasmodium falciparum Sporozoites (PfRAS) (true-immunization) or noninfected (mock-immunization).
 
Overall design Comparison of RNAseq results from two cohorts each with two treatments, true-immunization and mock-immunization, across multiple timepoints from baseline to post-1st vaccination (Day 0, 1, 3, 7, 14, 28) to assess biomarkers of clinically-defined protection. This Series includes the data from Cohort 1.
 
Contributor(s) Epstein J, Du Y, Duffy F, Carnes J, Stuart K
Citation(s) 35108339, 34243763
NIH grant(s)
Grant ID Grant title Affiliation Name
U19 AI128914 Immune Responses to Malaria and HIV Infection and Immunization SEATTLE CHILDREN'S RESEARCH INSTITUTE KENNETH D STUART
Submission date Jul 03, 2018
Last update date Feb 22, 2022
Contact name Raphael Gottardo
Organization name Fred Hutch
Department VIDD
Lab Gottardo
Street address 1100 Fairview Ave N
City Seattle
State/province WA
ZIP/Postal code 98109
Country USA
 
Platforms (2)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
GPL23227 BGISEQ-500 (Homo sapiens)
Samples (67)
GSM3243835 Subject 060 VisitDay 028 Cohort IMRAS_Cohort 1_True Immunized
GSM3243836 Subject 061 VisitDay 028 Cohort IMRAS_Cohort 1_True Immunized
GSM3243840 Subject 057 VisitDay 028 Cohort IMRAS_Cohort 1_True Immunized
Relations
BioProject PRJNA479519
SRA SRP151948

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE116619_GEO_IMRAS_mapped_rawCounts.tsv.gz 1.8 Mb (ftp)(http) TSV
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

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