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| Status |
Public on Sep 02, 2020 |
| Title |
Glucocorticoids enhance the anti-leukemic activity of FLT3 inhibitors in FLT3 mutant acute myeloid leukemia |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Utilizing genome wide transcriptome analysis and drug screen we demonstrate that upregulation of inflammatory pathways is a key mechanism of drug tolerance to FLT3 targeted inhibitors in AML
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| |
|
| Overall design |
Performed RNA-seq after isolating cells that survive treatment with DMSO or quizartinib for 48h or after recovery in drug free media for 13 or 30 days. Another set of RNA-seq was performed using cells that survive treatment with DMSO, dexamethasone, quizartinib or the combination of quizartinib and dexamethasone for 48h or 5 days(in the case of combination tretment for 5days quizartinib was kept for 5 days but dexemethasone was added on Day 3).
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| |
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| Contributor(s) |
Gebru MT, Wang HG |
| Citation(s) |
32396937 |
| |
| Submission date |
Jun 28, 2018 |
| Last update date |
Sep 02, 2020 |
| Contact name |
Melat T Gebru |
| E-mail(s) |
melattata17@gmail.com
|
| Phone |
7175269259
|
| Organization name |
Penn State University
|
| Department |
Pediatrics
|
| Lab |
Hong-Gang Wang
|
| Street address |
95A University Manor East
|
| City |
Hershey |
| State/province |
PA |
| ZIP/Postal code |
17033 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
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| Samples (26)
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| Relations |
| BioProject |
PRJNA478462 |
| SRA |
SRP151611 |
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