NCBI Logo
GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
          Go
Series GSE116339 Query DataSets for GSE116339
Status Public on Aug 01, 2018
Title Exposure to polybrominated biphenyl (PBB) associates with DNA methylation differences across the genome
Organism Homo sapiens
Experiment type Methylation profiling by genome tiling array
Summary Polybrominated biphenyl (PBB) is an endocrine-disrupting compound which was accidently added to the food supply in Michigan in the 1970’s. Highly exposed individuals and their children have numerous health problems, though the underlying mechanism behind these health problems remains unknown. Other endocrine-disrupting compounds have been linked to epigenetic differences, but no epigenetic studies have been done for PBB. In this study, DNA from the blood of individuals with PBB exposure from the Michigan PBB Registry was interrogated with the MethylationEPIC BeadChip (N = 659). Associations between each of the ~850,000 CpG sites and current, serum PBB levels were tested with a linear regression that controlled for age, sex, and cell type proportions. We show that exposure to PBB is associated with differences in epigenetic marks that suggest that it is acting similarly to estrogen and is associated with dysregulated immune system pathways.
 
Overall design DNA methylation was assessed in peripheral blood from people exposed to polybrominated biphenyl (PBB). Peripheral blood DNA was extracted, bisulfite converted and genome-wide DNA methylation was interrogated using the HumanMethylationEPIC BeadChip (Illumina).
 
Contributor(s) Curtis SW, Kilaru V, Cobb DO, Marcus M, Conneely KN, Smith AK
Citation(s) 30676242
Submission date Jun 27, 2018
Last update date Jan 03, 2020
Contact name Sarah Whelan Curtis
E-mail(s) sarah.elizabeth.whelan@emory.edu
Organization name Emory University
Street address 101 Woodruff Circle NE, Ste 42
City Atlanta
State/province GA
ZIP/Postal code 30322
Country USA
 
Platforms (1)
GPL21145 Infinium MethylationEPIC
Samples (679)
GSM3228562 200550980002_R01C01
GSM3228563 200550980002_R02C01
GSM3228564 200550980002_R03C01
Relations
BioProject PRJNA478257

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE116339_Processed_Matrix.csv.gz 4.1 Gb (ftp)(http) CSV
GSE116339_RAW.tar 9.4 Gb (http)(custom) TAR (of IDAT)
Processed data are available on Series record

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap