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| Status |
Public on Dec 20, 2018 |
| Title |
Distinct stress response and altered striatal transcriptome in alpha-synuclein overexpressing mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Using a mouse model overexpressing human SNCA and profiling the striatal transcriptome, we assessed gene-environment interactions to reveal perturbations in gene expression and their modulation through chronic unpredictable mild stress (CUMS) exposure.
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| Overall design |
Using a 2x2 factorial design, we cross-compared a line of transgenic mice overexpressing human SNCA with wildtype animals, and the effects of chronic unpredictable mild stress (CUMS) with standard housing conditions. Employing RNA-seq, we profiled gene expression in the striatum of 6-month-old female animals.
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| Contributor(s) |
Schulze-Hentrich JM, Hentrich T |
| Citation(s) |
30686992 |
| |
| Submission date |
Jun 19, 2018 |
| Last update date |
Mar 21, 2019 |
| Contact name |
Julia Maria Schulze-Hentrich |
| E-mail(s) |
juliamschulze@gmail.com
|
| Organization name |
Saarland University
|
| Department |
Genetics and Epigenetics
|
| Street address |
Campus, Building A2.4
|
| City |
Saarbrücken |
| ZIP/Postal code |
66123 |
| Country |
Germany |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (13)
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| Relations |
| BioProject |
PRJNA476789 |
| SRA |
SRP150874 |
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