|
| Status |
Public on Aug 31, 2018 |
| Title |
Spatially Constrained Tandem Bromodomain Inhibition Bolsters Sustained Repression of BRD4 Transcriptional Activity for TNBC Cell Growth |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We performed RNA-seq of MDA-MB-231 cells that were treated with MS645 or JQ1 at 50 nM and 500 nM in an effort to understand how MS645 exerts such a profound cell growth inhibition on cancer cells.
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| |
|
| Overall design |
MDA-MB-231 cells were treated with DMSO and different concentrations of JQ1 and MS645 for 18 hrs to compare the compounds' effect in transcriptional regulation.
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| |
|
| Contributor(s) |
Ren C, Zhou M |
| Citation(s) |
30012592 |
| |
| Submission date |
Jun 10, 2018 |
| Last update date |
May 17, 2019 |
| Contact name |
MING-MING ZHOU |
| E-mail(s) |
ming-ming.zhou@mssm.edu
|
| Phone |
212-659-8652
|
| Organization name |
Icahn School of Medicine at Mount Sinai
|
| Street address |
1425 madison ave
|
| City |
new york |
| State/province |
NY |
| ZIP/Postal code |
10029 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
|
| Samples (15)
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| Relations |
| BioProject |
PRJNA475425 |
| SRA |
SRP150159 |
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