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| Status |
Public on Jan 11, 2019 |
| Title |
RNA-seq analysis of whole liver derived from endothelial specific TAK1 conditional knockout mice. |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
In this study we show that TGFβ-activated kinase 1 (TAK1), is crucial for ensuring EC survival on TNFα stimulation. EC-specific TAK1-knockout in adult mice resulted in rapid death of the animal due to destruction of intestinal and liver blood vessels. TNFα from myeloid cells responding to intestinal microbiota was responsible for EC death in the intestine and liver. Our results illuminate mechanisms ensuring survival of intestinal and liver EC under physiological conditions
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| Overall design |
Liver mRNA expression profiles derived from VEcadCreERT2/TAK1flox/flox mice injected by tamoxifen were generated by using HiSeq 2500 in triplicate.
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| Contributor(s) |
Hisamichi N, Jun-ichi S |
| Citation(s) |
30639056 |
| |
| Submission date |
May 31, 2018 |
| Last update date |
Mar 21, 2019 |
| Contact name |
Jun-ichi Suehiro |
| Organization name |
Kyorin University School of Medicine
|
| Department |
Department of Pharmacology and Toxicology
|
| Street address |
6-20-2, Shinkawa
|
| City |
Mitaka |
| State/province |
Tokyo |
| ZIP/Postal code |
181-8611 |
| Country |
Japan |
| |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA474046 |
| SRA |
SRP149497 |
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