|
| Status |
Public on Apr 16, 2019 |
| Title |
Transcriptomic analysis of the role of the integrin a6b4 in detached cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Analysis of gene expression profiles of matrix-detached cells with and without expression of ITGB4, in clustering and non-clustering conditions. The experiment tested the hypothesis that the integrin beta 4 (ITGB4) mediates a significant amount of pro-survival signaling in matrix-detached conditions. Expression of ITGB4 in cancer is correlated with poor patient survival and is impliated in increased metastatic spread. Survival in matrix-deprived conditions is essential to metastasis and targeting signaling downstream of the integrin beta 4 may help curtail metasasis.
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| |
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| Overall design |
Examination of gene expression profile following 3 hours of incubation in matrix-deprived conditions in duplicate
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| |
|
| Contributor(s) |
Brown C, Mercurio A |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
May 29, 2018 |
| Last update date |
Jul 16, 2019 |
| Contact name |
Marcus Ruscetti |
| E-mail(s) |
marcus.ruscetti@umassmed.edu
|
| Organization name |
Umass Chan Medical School
|
| Department |
MCCB
|
| Street address |
364 Plantation Street, LRB-613, LRB-613
|
| City |
Worcester |
| State/province |
MA |
| ZIP/Postal code |
01605 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA473581 |
| SRA |
SRP149286 |
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