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| Status |
Public on Dec 05, 2019 |
| Title |
RNA sequencing data of Wild Type and Fmr1 KO hippocampal neuron |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Fragile X syndrome (FXS), caused by mutations in fragile X mental retardation 1 gene (FMR1), is a prevailing genetic disorder of intellectual disability and autism. Analysis of transcriptome outcome (differentially expressed genes between WT and Fmr1 KO hippocampal neuron) associated with FXS reveal promising value of gene signature-based computation in repurposing drugs for potential practical treatment.
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| Overall design |
Primary DIV (Days in vitro) 14 Hippocampal neuron mRNA profiles of Wild Type (WT) and Fmr1 KO mice were generated in triplicate
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| |
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| Contributor(s) |
Wang H, Sethna F, Ding Q, Wu X, Chen P, Miao Z, Zhang Y, Xiao H, Feng W, Feng Y, Li X |
| Citation(s) |
32179850 |
| |
| Submission date |
May 03, 2018 |
| Last update date |
Mar 30, 2020 |
| Contact name |
Zhuang Miao |
| E-mail(s) |
miaozhua@msu.edu
|
| Organization name |
Michigan State University
|
| Department |
Physiology
|
| Lab |
Hongbing Wang
|
| Street address |
567 Wilson Road
|
| City |
East Lansing |
| State/province |
Michigan |
| ZIP/Postal code |
48824 |
| Country |
USA |
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| Platforms (1) |
| GPL13112 |
Illumina HiSeq 2000 (Mus musculus) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA454880 |
| SRA |
SRP144498 |
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