|
| Status |
Public on May 17, 2018 |
| Title |
Profiling of lung tumor-infiltrating CD8 T cells according to their expression status of CD39 |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Human tumors are infiltrated by various immune cells, including CD8 T cells. CD8 T cells express unique receptors that can recognize peptides at the host’s cells, including tumor cells. After probing the antigen specificity of ex-vivo tumor-infiltrating CD8 T cells from human tumors, we hypothesized that expression of CD39 was correlated with tumor-specificity. The present experiment aims at better characterizing ex-vivo CD39+ vs CD39- CD8 T cells.
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| |
|
| Overall design |
CD39- and CD39+ CD8 T cells were FACS sorted from 8 fresh tumor samples and their RNA extracted for transcriptomic profiling.
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| |
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| Contributor(s) |
Simoni Y, Duan K, Lum J, Newell E |
| Citation(s) |
29769722 |
| |
| Submission date |
Apr 24, 2018 |
| Last update date |
Mar 21, 2019 |
| Contact name |
Kaibo Duan |
| E-mail(s) |
duan_kaibo@immunol.a-star.edu.sg
|
| Organization name |
Singapore Immunology Network
|
| Street address |
8A Biomedical Grove, Immunos Building, Level 4
|
| City |
Singapore |
| ZIP/Postal code |
138648 |
| Country |
Singapore |
| |
|
| Platforms (1) |
| GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
|
| Samples (8)
|
| GSM3109339 |
NSCLC_Tumor infiltrating CD39- CD8 T cells 1 |
| GSM3109340 |
NSCLC_Tumor infiltrating CD39+ CD8 T cells 1 |
| GSM3109341 |
NSCLC_Tumor infiltrating CD39- CD8 T cells 2 |
| GSM3109342 |
NSCLC_Tumor infiltrating CD39+ CD8 T cells 2 |
| GSM3109343 |
NSCLC_Tumor infiltrating CD39- CD8 T cells 3 |
| GSM3109344 |
NSCLC_Tumor infiltrating CD39+ CD8 T cells 3 |
| GSM3109345 |
NSCLC_Tumor infiltrating CD39- CD8 T cells 4 |
| GSM3109346 |
NSCLC_Tumor infiltrating CD39+ CD8 T cells 4 |
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| This SubSeries is part of SuperSeries: |
| GSE113590 |
Profiling of tumor-infiltrating CD8 T cells according to their expression status of CD39 |
|
| Relations |
| BioProject |
PRJNA453180 |
| SRA |
SRP142465 |
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