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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Dec 25, 2018 |
| Title |
Characterization of myocardial B cells in naïve hearts, acutely injured hearts and acutely injured hearts of mice treated with Pirfenidone |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Myocardial CD19+CD11b+ and CD19+CD11b- cells were FACS sorted from transgenic mice expressing the Diphtheria Toxin (DT) receptor under the myocardial specific MLC2v promoter. Cells were sorted from hearts of mice not exposed to DT (naïve hearts), from the hearts of animals treated with DT 4 days prior to the experiment (DTR) and from the hearts of mice exposed to DT and fed chow enriched with the anti-inflammatory/anti-fibrotic drug Pirfenidone (0.5% in powdered chow, PFD)
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| Overall design |
Cells sorted from naïve hearts were compared to cells sorted from DTR injured hearts and to cells sorted from the hearts of DTR injured animals treated with Pirfenidone
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| Contributor(s) |
Adamo L, Matkovich SJ, Mann DL |
| Citation(s) |
29875326 |
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| Submission date |
Apr 11, 2018 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Scot J Matkovich |
| E-mail(s) |
sjmatkovich@lilly.com
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| Organization name |
Eli Lilly and Company
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| Street address |
Lilly Corporate Center
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| City |
Indianapolis |
| State/province |
IN |
| ZIP/Postal code |
46285 |
| Country |
USA |
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| Platforms (1) |
| GPL21493 |
Illumina HiSeq 3000 (Mus musculus) |
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| Samples (34)
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| GSM3092647 |
set1, Myocardial DTR transgenic, CD19+CD11b-, DT-treated, 10 |
| GSM3092648 |
set1, Myocardial DTR transgenic, CD19+CD11b+, DT-treated, 11 |
| GSM3092649 |
set1, Myocardial DTR transgenic, CD19+CD11b-, DT-treated, 12 |
| GSM3092650 |
set1, Myocardial DTR transgenic, CD19+CD11b+, DT-treated, 13 |
| GSM3092651 |
set1, Myocardial DTR transgenic, CD19+CD11b-, DT-treated, 14 |
| GSM3092652 |
set1, Myocardial DTR transgenic, CD19+CD11b+, DT-treated, 15 |
| GSM3092653 |
set1, Myocardial DTR transgenic, CD19+CD11b-, DT-treated, 16 |
| GSM3092654 |
set1, Myocardial DTR transgenic, CD19+CD11b+, DT-treated, 9 |
| GSM3092655 |
set1, Myocardial DTR transgenic, CD19+CD11b+, DT+PFD-treated, 17 |
| GSM3092656 |
set1, Myocardial DTR transgenic, CD19+CD11b-, DT+PFD-treated, 18 |
| GSM3092657 |
set1, Myocardial DTR transgenic, CD19+CD11b+, DT+PFD-treated, 19 |
| GSM3092658 |
set1, Myocardial DTR transgenic, CD19+CD11b-, DT+PFD-treated, 20 |
| GSM3092659 |
set1, Myocardial DTR transgenic, CD19+CD11b+, DT+PFD-treated, 21 |
| GSM3092660 |
set1, Myocardial DTR transgenic, CD19+CD11b-, DT+PFD-treated, 22 |
| GSM3092661 |
set1, Myocardial DTR transgenic, CD19+CD11b+, no DT, no PFD, 1 |
| GSM3092662 |
set1, Myocardial DTR transgenic, CD19+CD11b-, no DT, no PFD, 2 |
| GSM3092663 |
set1, Myocardial DTR transgenic, CD19+CD11b+, no DT, no PFD, 3 |
| GSM3092664 |
set1, Myocardial DTR transgenic, CD19+CD11b-, no DT, no PFD, 4 |
| GSM3092665 |
set1, Myocardial DTR transgenic, CD19+CD11b+, no DT, no PFD, 5 |
| GSM3092666 |
set1, Myocardial DTR transgenic, CD19+CD11b-, no DT, no PFD, 6 |
| GSM3092667 |
set1, Myocardial DTR transgenic, CD19+CD11b+, no DT, no PFD, 7 |
| GSM3092668 |
set1, Myocardial DTR transgenic, CD19+CD11b-, no DT, no PFD, 8 |
| GSM3092669 |
set2, Myocardial DTR transgenic, CD19+CD11b-, DT-treated, 1 |
| GSM3092670 |
set2, Myocardial DTR transgenic, CD19+CD11b+, DT-treated, 1 |
| GSM3092671 |
set2, Myocardial DTR transgenic, CD19+CD11b-, DT-treated, 2 |
| GSM3092672 |
set2, Myocardial DTR transgenic, CD19+CD11b+, DT-treated, 2 |
| GSM3092673 |
set2, Myocardial DTR transgenic, CD19+CD11b-, no DT, no PFD, 5a |
| GSM3092674 |
set2, Myocardial DTR transgenic, CD19+CD11b+, no DT, no PFD, 5a |
| GSM3092675 |
set2, Myocardial DTR transgenic, CD19+CD11b-, no DT, no PFD, 6a |
| GSM3092676 |
set2, Myocardial DTR transgenic, CD19+CD11b+, no DT, no PFD, 6a |
| GSM3092677 |
set2, Myocardial DTR transgenic, CD19+CD11b-, no DT, no PFD, 7a |
| GSM3092678 |
set2, Myocardial DTR transgenic, CD19+CD11b+, no DT, no PFD, 7a |
| GSM3092679 |
set2, Myocardial DTR transgenic, CD19+CD11b-, no DT, no PFD, 8a |
| GSM3092680 |
set2, Myocardial DTR transgenic, CD19+CD11b+, no DT, no PFD, 8a |
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| Relations |
| BioProject |
PRJNA449679 |
| SRA |
SRP139558 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE112984_depth-normalized_batch-corrected_cpm-filtered_HTSeq-data.txt.gz |
926.4 Kb |
(ftp)(http) |
TXT |
| GSE112984_unprocessed_HTSeq-data.txt.gz |
1.9 Mb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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