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| Status |
Public on Sep 01, 2018 |
| Title |
Gene expression analysis in lungs of Mtb infected Fth+/+ and Fth-/- mice by employing RNA-Seq |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Next-generation sequencing (NGS) has revolutionized systems-based analysis of cellular pathways. The goals of this study is to compare gene expression (RNA-seq) profile between Mtb infected Fth+/+ and Fth-/- mice at 9 weeks post Mtb infection. Gene expression analysis demonstrated an essential role for FtH in mitochondrial function and maintenance of central intermediary metabolism in vivo
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| |
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| Overall design |
Total RNA was isolated from lungs of Mtb infected Fth+/+ and Fth-/- mice at 9 weeks post infection
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| |
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| Contributor(s) |
Steyn AJ, Reddy VP |
| Citation(s) |
29774023 |
| |
| Submission date |
Mar 27, 2018 |
| Last update date |
Mar 21, 2019 |
| Contact name |
Adrie JC Steyn |
| E-mail(s) |
asteyn@uab.edu
|
| Phone |
205-996-4805
|
| Organization name |
University of Alabama at Birmingham
|
| Department |
Microbiology
|
| Lab |
845, 19th St S
|
| Street address |
308, BBRB
|
| City |
Birmingham |
| State/province |
AL |
| ZIP/Postal code |
35205 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA445797 |
| SRA |
SRP136522 |
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