|
| Status |
Public on Feb 25, 2020 |
| Title |
Gene expression profiling identifies a gene signature that predicts progression to active tuberculosis several years before disease onset |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We evaluated the predictive ability of various gene signatures in baseline peripheral blood mononuclear cell samples to distinguish Mtb-infected individuals who eventually progress to TB disease (progressors) or who remain asymptomatic (non-progressors) during clinical follow-up; we also compare long-term Mtb-infected non-progressors from patients with TB disease
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| |
|
| Overall design |
Transcriptome profiles via RNAseq of progressors, non-progressors, and TB patients in a Brazilian household contact cohort were used to identify a gene signature predictive of progression to TB
|
| |
|
| Contributor(s) |
Salgame P, Johnson WE, Leong S, Zhao Y |
| Citation(s) |
32090859 |
| |
| Submission date |
Mar 20, 2018 |
| Last update date |
Feb 25, 2020 |
| Contact name |
Padmini Salgame |
| E-mail(s) |
padmini.salgame@rutgers.edu
|
| Organization name |
Rutgers New Jersey Medical School
|
| Department |
Medicine
|
| Lab |
Salgame
|
| Street address |
185 South Orange Ave
|
| City |
Newark |
| State/province |
NJ |
| ZIP/Postal code |
07103 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
|
| Samples (51)
|
|
| Relations |
| BioProject |
PRJNA439289 |
| SRA |
SRP136109 |
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