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Series GSE111708 Query DataSets for GSE111708
Status Public on Mar 12, 2019
Title Abnormalities in Prefrontal Cortical Gene Expression Profiles Relevant to Schizophrenia in MK801-Exposed C57BL/6 Mice.
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary MK-801, a non-competitive NMDA receptor (NMDAR) antagonist, disturbs NMDAR function in rodents and induces psychological and behavioral changes similar to schizophrenia(SCZ). However, the effects of MK-801 treatment on gene expression in prefrontal cortex (PFC) are largely unknown. We have established MK-801 animal models to explore the etiology and pathophysiology of schizophrenia. Transcriptome analysis of the prefrontal cortex reveals that the differentially expressed genes mainly aggregate in chemical synaptic transmission and immune system process. Gene association patterns which are involved in synaptic vesicle cycle and mitochondrial electron transport chain have also been altered. Together, these observations underscore that dysfunction in glutamatergic synaptic vesicle cycle and mitochondrial electron transport chain has an impact on the pathogenesis of SCZ.
Overall design Prefrontal cortex mRNA profiles of three saline control mice and six MK801-exposed mice were generated by RNA-seq, using Illumina X-10.
Contributor(s) Ye H, Zhao J
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Submission date Mar 12, 2018
Last update date Mar 13, 2019
Contact name Jialu Zhao
Organization name Capital Medical University
Street address You an men wai Xi tou tiao Road 10
City Beijing
ZIP/Postal code 100069
Country China
Platforms (1)
GPL21273 HiSeq X Ten (Mus musculus)
Samples (9)
GSM3037812 Control_1
GSM3037813 Control_2
GSM3037814 Control_3
BioProject PRJNA437940
SRA SRP134948

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Supplementary file Size Download File type/resource
GSE111708_RAW.tar 9.3 Mb (http)(custom) TAR (of FPKM_TRACKING)
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Raw data are available in SRA
Processed data provided as supplementary file

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