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| Status |
Public on Mar 19, 2019 |
| Title |
Whole breast tissue gene expression in comparison to expression in epithelial and stromal tissues |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
The breast tissue contains both epithelial and stromal tissues in its composition. In this substudy we compared the gene expression of the whole core needle biopsy of the breast with the expression observed in its epithelia and stroma.
Laser capture microdissection was performed to compare the gene expression profile in the whole breast biopsy with that in the epithelial and stromal tissues. In this study we had samples collected from nive premenopausal women, free of any breast abnormality.
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| Overall design |
For each of nine women included in this substudy, three microarrays were performed in the same batch, using RNA extracted from 1) the epithelial cells of the mammary gland, 2) the stroma and 3) whole tissue. For each subject a linear regression model was fitted across all genes. The gene expression values in the whole tissue were modeled as a linear function of the gene expression in epithelial and stromal tissues.
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| Contributor(s) |
Santucci-Pereira J, Zeleniuch-Jacquotte A, Afanasyeva Y, Zhong H, Slifker M, Peri S, Ross EA, López de Cicco R, Zhai Y, Nguyen T, Sheriff F, Russo IH, Su Y, Arslan AA, Bordas P, Lenner P, Åhman J, Landström-Eriksson6 A, Johansson R, Hallmans G, Toniolo P, Russo J |
| Citation(s) |
30922380 |
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| Submission date |
Mar 11, 2018 |
| Last update date |
Apr 17, 2019 |
| Contact name |
Julia Santucci-Pereira |
| E-mail(s) |
ju.delbuono@gmail.com
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| Organization name |
Fox Chase Cancer Center
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| Lab |
The Irma H. Russo, MD Breast Cancer Research Laboratory
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| Street address |
333 Cottman Ave, P2051
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| City |
Philadelphia |
| State/province |
PA |
| ZIP/Postal code |
19111 |
| Country |
USA |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (27)
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| Relations |
| BioProject |
PRJNA437765 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE111662_RAW.tar |
111.6 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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