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| Status |
Public on Jan 27, 2019 |
| Title |
mRNA sequence Analysis of Apocynin treated MKN45 |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Noxo1, a component of NADPH oxidase 1 (NOX1) complex, is upregulated in gastric cancer cells in a inflammation-dependent manner, and plays an important role in tumorigenesis (Oncogene, 33: 3820, 2014). To examine the mechanism of NOX1/ROS signaling in tumorigenesis, MKN45 gastric cancer cells were treated with apocynin, an inhibitor for NOX, and their gene expression was examined by RNA sequencing. Based on expression data, Sox2 was shown to be suppressed by apocynin, suggesting a role of Sox2 in a inflammation-associated gastric tumorigenesis.
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| |
|
| Overall design |
Total mRNA expression profiles of Apocynin administrated MKN45 in 2 trials.
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| |
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| Contributor(s) |
Oshima M, Yamada Y, Echizen K |
| Citation(s) |
30700829 |
| |
| Submission date |
Mar 07, 2018 |
| Last update date |
Oct 01, 2019 |
| Contact name |
masanobu oshima |
| E-mail(s) |
oshimam@staff.kanazawa-u.ac.jp
|
| Organization name |
kanazawa university
|
| Street address |
Kakuma-machi
|
| City |
kanazawa |
| ZIP/Postal code |
920-1164 |
| Country |
Japan |
| |
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| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA437294 |
| SRA |
SRP134098 |
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