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| Status |
Public on Nov 20, 2018 |
| Title |
Distinct constitutive and pathogen-induced transcriptional programs in dendritic cells derived from CD16- versus CD16+ monocytes |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Classical CD16- versus intermediate/non-classical CD16+ monocytes differ in their homing potential and immunological functions; but whether they differentiate into dendritic cells (DC) with distinct contributions to immunity against bacterial/viral pathogens remains poorly investigated. Here, we employed a systems biology approach to identify differences between CD16+ and CD16- monocyte-derived DC (MDDC) with potential clinical relevance
Although both CD16+ and CD16- MDDC acquire classical DC markers in vitro, genome-wide transcriptional profiling revealed unique molecular signatures for CD16+ MDDC, including adhesion molecules (CD103), transcription factors (TCF4), enzymes (ALDH1L2), and chemokines (CCL22).
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| Overall design |
30 samples. 5 donors x 2 cell populations (CD16+/CD16-) x 3 conditions (media, HIV, LPS)
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| Contributor(s) |
Wacleche VS, Goulet J, Cattin A, Gauchat D, Gosselin A, Cleret-Buhot A, Zhang Y, Tremblay C, Routy J, Ancuta P |
| Citation(s) |
30381402 |
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| Submission date |
Mar 06, 2018 |
| Last update date |
Mar 15, 2019 |
| Contact name |
Jean-Philippe Goulet |
| E-mail(s) |
jp.goulet@umontreal.ca
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| Organization name |
Université de Montréal
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| Street address |
C.P. 6128, succursale Centre-ville
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| City |
Montréal |
| State/province |
Québec |
| ZIP/Postal code |
H3X 3J7 |
| Country |
Canada |
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| Platforms (1) |
| GPL16686 |
[HuGene-2_0-st] Affymetrix Human Gene 2.0 ST Array [transcript (gene) version] |
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| Samples (30)
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| Relations |
| BioProject |
PRJNA437144 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE111474_RAW.tar |
242.7 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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