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| Status |
Public on Mar 01, 2019 |
| Title |
The Role of JNK1/2 in Mouse Lung Squamous Cell Carcinoma (SCC) Development |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Lung cancer is the leading cause of cancer death in USA. Squamous Cell Carcinoma (SCC) is one of the subtypes of lung cancer. It is still largely unknown which genes or pathways regulate lung SCC development. Recently, we found JNK1/2 pathway was inhibited in mouse lung SCC induced by double ablation of Pten and Lkb1 in mouse lung epithelial cells. Now we aim to identify a genome-wide molecular signature of JNK1/2 signaling in mouse squamous cell carcinoma cells and determine pathways that transduce JNK1/2 signaling.
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| Overall design |
We will compare gene expression levels in mouse SCC cells in gRNA -Control group and gRNA-Jnk1/2 group.
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| Contributor(s) |
Liu J, DeMayo FJ |
| Citation(s) |
31089135 |
| |
| Submission date |
Mar 01, 2018 |
| Last update date |
May 21, 2019 |
| Contact name |
Jian Liu |
| E-mail(s) |
JianL@intl.zju.edu.cn
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| Organization name |
Zhejiang University
|
| Department |
Zhejiang University - University of Edinburgh Institute
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| Lab |
Jian Liu's lab
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| Street address |
718 East Haizhou Rd.
|
| City |
Haining |
| State/province |
Zhejiang |
| ZIP/Postal code |
314400 |
| Country |
China |
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| Platforms (1) |
| GPL7202 |
Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA436646 |
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