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| Status |
Public on Mar 17, 2020 |
| Title |
Activation of the VEGFC/VEGFR3 pathway induces cancer immune escape through tumor-associated lymphatic vessels and macrophages in colorectal cancer |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Colorectal cancer (CRC) is one of the major causes of cancer-related death in Western countries and is associated with increased numbers of lymphatic vessels (LVs) and tumor-associated macrophages (TAMs). The VEGFC/VEGFR3 pathway is regarded as the principal inducer of lymphangiogenesis and it contributes to metastases; however, no data are available on its role during CRC development. We found that both VEGFC and VEGFR3 were upregulated in human non-metastatic CRC, with VEGFR3 localising on both LVs and TAMs. We further proved in different preclinical models of CRC, that VEGFC/VEGFR3 axis can shape both LECs and TAMs to synergically inhibit anti-tumor immunity and promote primary CRC growth. VEGFR3-directed therapy could be envisioned for the treatment of non-metastatic CRC.
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| Overall design |
n=8 Lymphatic cell samples and n=8 Macrophage samples with or without anti-VEGFR3 treatment.
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| |
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| Contributor(s) |
Tacconi C, D'Alessio S, Ungaro F, Danese S, Massimino L |
| Citation(s) |
31239267 |
| Submission date |
Feb 22, 2018 |
| Last update date |
Mar 20, 2020 |
| Contact name |
Luca Massimino |
| E-mail(s) |
admin@lucamassimino.com
|
| Phone |
3389039500
|
| Organization name |
Ospedale San Raffaele
|
| Department |
Gastroenterology
|
| Street address |
Via Olgettina, 58
|
| City |
Milano |
| State/province |
MI |
| ZIP/Postal code |
20100 |
| Country |
Italy |
| |
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| Platforms (1) |
| GPL21290 |
Illumina HiSeq 3000 (Homo sapiens) |
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| Samples (16)
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| Relations |
| BioProject |
PRJNA435506 |
| SRA |
SRP133273 |
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