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Series GSE110990 Query DataSets for GSE110990
Status Public on Mar 17, 2020
Title Activation of the VEGFC/VEGFR3 pathway induces cancer immune escape through tumor-associated lymphatic vessels and macrophages in colorectal cancer
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Colorectal cancer (CRC) is one of the major causes of cancer-related death in Western countries and is associated with increased numbers of lymphatic vessels (LVs) and tumor-associated macrophages (TAMs). The VEGFC/VEGFR3 pathway is regarded as the principal inducer of lymphangiogenesis and it contributes to metastases; however, no data are available on its role during CRC development. We found that both VEGFC and VEGFR3 were upregulated in human non-metastatic CRC, with VEGFR3 localising on both LVs and TAMs. We further proved in different preclinical models of CRC, that VEGFC/VEGFR3 axis can shape both LECs and TAMs to synergically inhibit anti-tumor immunity and promote primary CRC growth. VEGFR3-directed therapy could be envisioned for the treatment of non-metastatic CRC.
Overall design n=8 Lymphatic cell samples and n=8 Macrophage samples with or without anti-VEGFR3 treatment.
Contributor(s) Tacconi C, D'Alessio S, Ungaro F, Danese S, Massimino L
Citation(s) 31239267
Submission date Feb 22, 2018
Last update date Mar 20, 2020
Contact name Luca Massimino
Phone 3389039500
Organization name Ospedale San Raffaele
Department Gastroenterology
Street address Via Olgettina, 58
City Milano
State/province MI
ZIP/Postal code 20100
Country Italy
Platforms (1)
GPL21290 Illumina HiSeq 3000 (Homo sapiens)
Samples (16)
GSM3019780 Lymphatic VEGFR3 #1
GSM3019781 Lymphatic VEGFR3 #2
GSM3019782 Lymphatic VEGFR3 #3
BioProject PRJNA435506
SRA SRP133273

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Supplementary file Size Download File type/resource
GSE110990_RAW.tar 4.6 Mb (http)(custom) TAR (of TAB)
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Raw data are available in SRA
Processed data provided as supplementary file

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