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| Status |
Public on Apr 28, 2020 |
| Title |
RNA-seq gene expression profiling of livers from wild-type male and female mice, and from mice with a Double Knockout (DKO) of Ezh1 and Ezh2. |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
PolyA-selected RNA isolated from livers of adult male and female mice with a combined loss of EZH1 and EZH2 in hepatocytes was analyzed by RNA-seq. The DKO mouse model used in these analyses is a global deletion of Ezh1 and hepatocyte-specific deletion of Ezh2, and is described in Bae WK, Kang K, Yu JH, Yoo KH, Factor VM, Kaji K, Matter M, Thorgeirsson S, Hennighausen L. FASEB J. 2015 May;29(5):1653-62. doi: 10.1096/fj.14-261537. PMID: 25477280
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| Overall design |
Liver RNA, polyA-selected, was isolated from 7 week old male and female DKO mice (Ezh1-/-, Ezh2-f/f_Alb-Cre) and their floxed (f) controls. RNA samples from n=3 mouse livers were pooled to make each of 3 biological replicate libraries per sex and genotype. AC, Albumin-Cre
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| Contributor(s) |
Lau-Corona D, Waxman DJ |
| Citation(s) |
32428001 |
| NIH grant(s) |
| Grant ID |
Grant title |
Affiliation |
Name |
| R01 DK121998 |
Growth Hormone Regulation of Sex Differences in Liver Metabolism |
BOSTON UNIVERSITY CHARLES RIVER CAMPUS |
DAVID J WAXMAN |
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| |
| Submission date |
Feb 20, 2018 |
| Last update date |
May 22, 2020 |
| Contact name |
David J. Waxman |
| E-mail(s) |
djw@bu.edu
|
| Organization name |
Boston University
|
| Department |
Department of Biology and Bioinformatics Program
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| Street address |
5 Cummington Mall
|
| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02215 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (12)
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| This SubSeries is part of SuperSeries: |
| GSE110934 |
Gene expression and histone marks in EZH1/EZH2 double knockout mouse liver |
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| Relations |
| BioProject |
PRJNA434735 |
| SRA |
SRP133172 |
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