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| Status |
Public on Apr 21, 2018 |
| Title |
Dimethyl itaconate inhibits secondary wave of NF-κB signaling in macrophage activation |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Natural metabolite itaconate and its membrane permeable derivative dimethyl itaconate (DI) selectively inhibit a subset of cytokines during macrophage activation (e.g. IL-1β, IL-6, IL-12 but not TNF-α). Selectivity of DI action stems from the inhibitory effects of secondary, but not primary, wave of NF-κB signaling.
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| Overall design |
Bone marrow-derived macrophages (BMDMs) from C57BL/6 mice were stimulated with LPS + IFNg for indicated timepoints. Some samples were treated with dimethyl itaconate for 12h prior to LPS stimulation.
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| Contributor(s) |
Bambouskova M, Lampropoulou V, Sergushichev A, Artyomov MN |
| Citation(s) |
29670287 |
| |
| Submission date |
Feb 16, 2018 |
| Last update date |
Mar 21, 2019 |
| Contact name |
Maxim N. Artyomov |
| E-mail(s) |
martyomov@pathology.wustl.edu
|
| Organization name |
Washington University in St.Louis
|
| Department |
Immunology&Pathology
|
| Street address |
660 S. Euclid Avenue, Campus Box 8118
|
| City |
St.Louis |
| State/province |
MO |
| ZIP/Postal code |
63110 |
| Country |
USA |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (20)
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| Relations |
| BioProject |
PRJNA434457 |
| SRA |
SRP133013 |
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