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Series GSE110685 Query DataSets for GSE110685
Status Public on May 09, 2018
Title Low density granulocytes and their gene signature associate with vascular inflammation and coronary atheroclerosis in systemic lupus erythematosus patients
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Patients with systemic lupus erythematosus (SLE) display an increased risk of cardiovascular disease that is not fully explained by traditional risk factors. This study correlated RNA sequencing data from whole blood of patients with SLE and healthy controls with markers of cardiovascular risk including coronary plaque measured by CT angiogram and vascular inflammation by FDG-PET CT.
Overall design This dataset includes a total of 53 individual samples from two independent RNAseq runs. This study sought to compare healthy controls to SLE patients and to determine transcriptomic differences in patients that developed vascular damage to those without vascular impairments. The first run compared SLE patients with high noncalcified plaque burdens (NCB) (>1.5 standard deviations of healthy control mean), measured by coronary CT angiography, and patients that had NCB comparable to healthy controls (within 1.5 standard deviations of healthy control mean). The second run validated these findings and compared patients with high vascular inflammation (>1.5 standard deviations of healthy control mean), as measured by target:background ratio (TBR) on FDG-PET/CT scans, to patients with vascular inflammation comparable to healthy controls (within 1.5 standard deviations of healthy control mean).
Contributor(s) Carlucci PM, Purmalek MM, Sun HW, Gutierrez-Cruz G, Mehta N, Kaplan MJ
Citation(s) 29669944
Submission date Feb 15, 2018
Last update date Mar 27, 2019
Contact name Hong-wei Sun
Organization name NIAMS
Department Office of Science & Technology
Lab Biodata Mining & Discovery Section
Street address 9000 Rockville Pile
City Bethesda
State/province MD
ZIP/Postal code 20892
Country USA
Platforms (2)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
GPL21290 Illumina HiSeq 3000 (Homo sapiens)
Samples (53)
GSM3011776 mRNA_ctrl_1
GSM3011777 mRNA_lupus_LN_TBR_1
GSM3011778 mRNA_ctrl_2
BioProject PRJNA434274
SRA SRP132939

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Supplementary file Size Download File type/resource
GSE110685_PCarlucci_RNA-Seq_tc_rpkm_combined_submitted.xlsx 25.2 Mb (ftp)(http) XLSX
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Processed data are available on Series record

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