|
| Status |
Public on Aug 06, 2019 |
| Title |
YAP1 fusion proteins drive forebrain ependymoma tumorigenesis via the interaction with TEAD transcription factors |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
A mouse model has been generated resembling human YAP1 fusion-positive supratentorial ependymoma. We show that the YAP1-MAMLD1 fusion, which is the most recurrent fusion in this distinct type of ependymomas, is able to drive malignant transformation in mice. The resulting brain tumors resemble histo-molecular characteristics of their human counterparts.
|
| |
|
| Overall design |
Ten mouse brain tumors induced by electroporating either a human YAP1-MAMLD1 fusion construct or a human C11orf95-RELA fusion construct into cerebral ventricular zone cells of fetal mice at E13.5 were profiled on the Affymetrix Mouse Genome mm430.2 array.
|
| |
|
| Contributor(s) |
Pajtler K, Kawauchi D, Kool M |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Feb 14, 2018 |
| Last update date |
Aug 06, 2019 |
| Contact name |
Marcel Kool |
| E-mail(s) |
m.kool@dkfz.de
|
| Organization name |
German Cancer Research Center DKFZ
|
| Department |
Pediatric Neurooncology
|
| Street address |
Im Neuenheimer Feld 280
|
| City |
Heidelberg |
| ZIP/Postal code |
69120 |
| Country |
Germany |
| |
|
| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
|
| Samples (10)
|
|
| Relations |
| BioProject |
PRJNA434123 |
Less...
More...