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| Status |
Public on Apr 17, 2018 |
| Title |
Integration of human adipocyte chromosomal interactions with adipose gene expression prioritizes obesity-related genes from GWAS |
| Organism |
Homo sapiens |
| Experiment type |
Other
|
| Summary |
We perform promoter Capture Hi-C in human adipocytes to investigate interactions between gene promoters and distal elements as a transcription-regulating mechanism contributing to these phenotypes. We find that promoter-interacting elements in human adipocytes are enriched for adipose-related transcription factor motifs, such as PPARG and CEBPB, and contribute to heritability of cis-regulated gene expression.
David Pan was funded through
Grant Title: Biomedical Big Data Training Grant
Grant ID: T32LM012424
Funding Source: National Institutes of Health-National Cancer Institute
Marcus Alvarez was funded through
Grant Title: NIH training grant in Genomic Analysis and Interpretation
Grant ID: T32HG002536
Funding Source: National Institutes of Health
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| Overall design |
Promoter Capture Hi-C library was produced from human white adipocytes differentiated from primary human white preadipocytes
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| Contributor(s) |
Pan DZ, Garske KM, Pajukanta P, Ko A |
| Citation(s) |
29666371 |
| NIH grant(s) |
| Grant ID |
Grant title |
Affiliation |
Name |
| R01 HL095056 |
Genomics of dyslipidemia in Mexicans |
UNIVERSITY OF CALIFORNIA LOS ANGELES |
Paivi Pajukanta |
| R01 DK093757 |
Genetic epidemiology of rare and regulatory variants for metabolic traits |
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL |
Karen L. Mohlke |
| U01 DK105561 |
Functional genetic variants for type 2 diabetes |
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL |
Karen L. Mohlke |
| P01 HL028481 |
Systems genomics of metabolic syndrome traits |
UNIVERSITY OF CALIFORNIA LOS ANGELES |
Paivi Pajukanta |
| R00 HL121172 |
Systems genetics analysis of cardiometabolic trait loci in humans |
UNIVERSITY OF VIRGINIA CHARLOTTESVILLE |
Mete Civelek |
| F31 HL127921 |
Identification of lipid biomarkers via integrative genomic approaches in Hispanic populations |
UNIVERSITY OF CALIFORNIA LOS ANGELES |
arthur ko |
| P01 HL028481 |
Molecular Genetic Approaches in Atherosclerosis Research |
UNIVERSITY OF CALIFORNIA LOS ANGELES |
Aldons Jake Lusis |
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| |
| Submission date |
Feb 14, 2018 |
| Last update date |
Mar 21, 2019 |
| Contact name |
Kristina Marie Garske |
| E-mail(s) |
kmgarske@ucla.edu, kg8086@princeton.edu
|
| Organization name |
Princeton University
|
| Department |
Lewis-Sigler Institute for Integrative Genomics; Ecology & Evolutionary Biology
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| Lab |
Julien Ayroles
|
| Street address |
Carl Icahn Lab, South Drive, Princeton University
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| City |
Princeton |
| State/province |
New Jersey |
| ZIP/Postal code |
08540 |
| Country |
USA |
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| Platforms (1) |
| GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
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| Samples (1) |
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| Relations |
| BioProject |
PRJNA434114 |
| SRA |
SRP132876 |
