|
| Status |
Public on Nov 21, 2018 |
| Title |
Differential expression in wild type and mutant HAP1 cells [RNA-seq I] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
using RNA-seq we characterized gene expression changes occuring upon knockout of BAP1, ASXL1, ASXL2, ASXL1/2 or Polycomb genes RING1B and EZH2. We also investigated the response to retinoic acid treatment in wild-type and BAP1 KO cells.
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| |
|
| Overall design |
Examination of transcript abundance in wild-type HAP1 cells and in 9 different HAP1-mutated cell lines as well as upon retinoic acid treatment in wild-type and BAP1 KO cells. Two biological replicated were performed for each condition.
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| |
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| Contributor(s) |
Margueron R, Wassef M |
| Citation(s) |
30664650 |
| |
| Submission date |
Feb 05, 2018 |
| Last update date |
Mar 27, 2019 |
| Contact name |
Nicolas Servant |
| E-mail(s) |
Nicolas.Servant@curie.fr
|
| Organization name |
Institut Curie
|
| Street address |
26 rue d'ulm
|
| City |
Paris Cedex 05 |
| ZIP/Postal code |
75248 |
| Country |
France |
| |
|
| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
|
| Samples (44)
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| This SubSeries is part of SuperSeries: |
| GSE110143 |
BAP1 complex promotes transcription by opposing PRC1-mediated H2A ubiquitylation |
|
| Relations |
| BioProject |
PRJNA432944 |
| SRA |
SRP132194 |
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