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| Status |
Public on Aug 01, 2018 |
| Title |
Analysis of cabazitaxel-resistant mechanism in human castration-resistant prostate cancer |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
To investigate cabazitaxel (CBZ) resistance in prostate cancer, we examined the changes in global gene expression before and after development of acquired CBZ resistance. Functional annotation clustering (FAC) analysis of DAVID showed cell division (GO: 0051301) and mitotic nuclear division (GO: 0007067) were the most enhanced clusters in DU145CR compared with DU145.
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| Overall design |
DU145 and DU145CR cells were used for microarrays. DU145CR cells were newly established in our laboratory from DU145 cells as an acquired cabazitaxel resistant subline, which were grown and passaged upon reaching confluence in medium containing CBZ over a 18-month period.
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| Contributor(s) |
Kosaka T, Hongo H |
| Citation(s) |
34593983 |
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| Submission date |
Feb 05, 2018 |
| Last update date |
Apr 25, 2023 |
| Contact name |
Hiroshi Hongo |
| E-mail(s) |
hongo_blueskylover@hotmail.com
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| Phone |
81-3-5363-3825
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| Organization name |
Keio University School of Medicine
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| Department |
Urology
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| Street address |
35, Shinanomachi
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| City |
Shinjuku-ku |
| State/province |
Tokyo |
| ZIP/Postal code |
160-0016 |
| Country |
Japan |
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| Platforms (1) |
| GPL16686 |
[HuGene-2_0-st] Affymetrix Human Gene 2.0 ST Array [transcript (gene) version] |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA433108 |
