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| Status |
Public on May 01, 2018 |
| Title |
Global gene expression profiling reveal distinct molecular profiles between p53-sensitive and p53-resistant T-cell lymphomas |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
TP53 mutations occur in approximately 50% of all human tumors with increased frequency in aggressive cancers that are notoriously difficult to treat. Additionally, p53 missense mutations are remarkably predictive of refractoriness to chemo/radiotherapy in various malignancies. These observations have led to the development of mutant-p53 targeting agents that restore p53 function. An important unknown is which p53-mutant tumors will respond to p53 reactivation-based therapies. Here we found a heterogeneous impact on therapeutic response to p53 restoration, suggesting it will unlikely be effective as a single therapy.
The goal of the study was to identify the pathways conferring resistance or sensitivity to genetic p53 restoration in tumors with a p53 missense mutaiton
Results:We sequenced the transcriptome of tumors that were sensitive or resistant to p53 restoration and found that TNF signaling was activated in p53-sensitive tumors.
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| Overall design |
12 independent biological samples were analyzed to compare tumors that were sensitive (n=8) or resistant (n=4) to genetic p53 restoration
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| Contributor(s) |
Lozano G, Liu B, Larsson C |
| Citation(s) |
29440484 |
| |
| Submission date |
Jan 30, 2018 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Bin Liu |
| Organization name |
University of Texas MD Anderson Cancer Center
|
| Department |
Epigenetics and Molecular Carcinogenesis
|
| Lab |
bioinformatics
|
| Street address |
1808 Park Road 1C
|
| City |
Smithville |
| State/province |
TX |
| ZIP/Postal code |
78957 |
| Country |
USA |
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| Platforms (1) |
| GPL21493 |
Illumina HiSeq 3000 (Mus musculus) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA432239 |
| SRA |
SRP131795 |
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