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| Status |
Public on Apr 14, 2020 |
| Title |
The Transgenerational Effects of Prenatal Synthetic Glucocorticoids on the Hippocampus Cortex |
| Organism |
Cavia porcellus |
| Experiment type |
Expression profiling by high throughput sequencing
Methylation profiling by high throughput sequencing
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| Summary |
First generation animals (F1) were exposed to multiple courses of synthetic glucocorticoids in utero. Animals were then bred to produce second (F2) and third (F3) generation offspring. These animals underwent behavioural assessmenets before sacrifice. In this experiment the prefrontal cortex for F1, F2, and F3 female animals, as well as F1 males (Control and sGC) have been extracted via micro-punch and RNA has been extracted.
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| Overall design |
Methylation Analyses: F1: Control N=6, sGC N=6; F2: Control N=6, sGC N=6; F3: Control N=7, sGC N=5; RNA-Seq Analyses: F1: Control N=6, sGC N=5; F2: Control N=6, sGC N=6; F3: Control N=6, sGC N=7
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| Contributor(s) |
Constantinof A, Boureau L, Moisiadis VG, Szyf M, Matthews SG |
| Citation(s) |
31796763 |
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| Submission date |
Jan 29, 2018 |
| Last update date |
Apr 14, 2020 |
| Contact name |
Stephen Matthews |
| Organization name |
University of Toronto
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| Street address |
1 King's College Circle
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| City |
Toronto |
| State/province |
Ontario |
| ZIP/Postal code |
M5S1A8 |
| Country |
Canada |
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| Platforms (1) |
| GPL22346 |
Illumina HiSeq 2500 (Cavia porcellus) |
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| Samples (72)
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| Relations |
| BioProject |
PRJNA431992 |
| SRA |
SRP131653 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE109765_F1_HPC_Processed_data.txt.gz |
667.1 Kb |
(ftp)(http) |
TXT |
| GSE109765_F1_HPC_SNR_Meth_processed_data.txt.gz |
2.2 Mb |
(ftp)(http) |
TXT |
| GSE109765_F1window100_Meth_v85_processed_data.txt.gz |
1.6 Mb |
(ftp)(http) |
TXT |
| GSE109765_F2_HPC_100bpv85_Meth_processed_data.txt.gz |
1.4 Mb |
(ftp)(http) |
TXT |
| GSE109765_F2_HPC_Processed_data.txt.gz |
652.0 Kb |
(ftp)(http) |
TXT |
| GSE109765_F2_HPC_SNR_Meth_processed_data.txt.gz |
1.2 Mb |
(ftp)(http) |
TXT |
| GSE109765_F3_HPC_Processed_data.txt.gz |
709.1 Kb |
(ftp)(http) |
TXT |
| GSE109765_F3_HPC_SNR_processed_data.txt.gz |
1.7 Mb |
(ftp)(http) |
TXT |
| GSE109765_F3window100_Meth_v85_processed_data.txt.gz |
1.4 Mb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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