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Series GSE109596 Query DataSets for GSE109596
Status Public on Dec 18, 2018
Title Altered social behavior in mice carrying a cortical Foxp2 deletion
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Genetic disruptions of the forkhead box transcription factor FOXP2 in humans cause an autosomal-dominant speech and language disorder. While FOXP2 expression pattern are highly conserved, its role in specific brain areas for mammalian social behaviors remains largely unknown. Here we studied mice carrying a homozygous cortical Foxp2 deletion. The postnatal development and gross morphological architecture of mutant mice was indistinguishable from wildtype (WT) littermates. Unbiased behavioral profiling of adult mice revealed abnormalities in approach behavior towards conspecifics as well as in the reciprocal responses of WT interaction partners. Furthermore mutant mice showed alterations in acoustical parameters of ultrasonic vocalizations (USV), which also differed in function of the social context. Cell type-specific gene expression profiling of cortical pyramidal neurons revealed aberrant regulation of genes involved in social behavior. In particular Foxp2 mutants showed the downregulation of Mint2 (Apba2), a gene involved in approach behavior in mice and autism spectrum disorder in humans. Taken together these data demonstrate that cortical Foxp2 is required for normal social behaviors in mice.
Overall design Wild-type mice and mice carrying a heterozygous Foxp2 deletion in the cortex were analyzed by RNA sequencing
Contributor(s) Medvedeva VP, Ziegenhain C
Citation(s) 30357341
Submission date Jan 24, 2018
Last update date Dec 19, 2018
Contact name Christoph Ziegenhain
Organization name Ludwig-Maximilians University Munich
Department Department Biology II
Lab Anthropology & Human genomics
Street address GroƟhaderner Str. 2
City Martinsried
State/province Bavaria
ZIP/Postal code 82152
Country Germany
Platforms (1)
GPL18480 Illumina HiSeq 1500 (Mus musculus)
Samples (20)
GSM2946913 het729IP
GSM2946914 het729IN
GSM2946915 het730IX
BioProject PRJNA431442
SRA SRP131277

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Supplementary file Size Download File type/resource
GSE109596_Medvedeva_counts.txt.gz 599.9 Kb (ftp)(http) TXT
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