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| Status |
Public on Oct 04, 2023 |
| Title |
Cyclosporin A inhibits prostate cancer growth through suppression of E2F8 |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Cyclosporin A (CsA) is a potent immunosuppressive agent used clinically in organ transplantation. In this study, we examined that CsA exerts anti-tumor activity against prostate cancer. We performed microarray experiments to investigate the effect of CsA on the transcriptome of prostate cancer cells. CsA potently induced transcriptome change and primarily affected cell cycle-related gene signatures. These results suggest that CsA can be used as a potential therapeutic agent or an intriguing tool for exploring prostate cancer biology and identifying novel therapeutic targets.
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| Overall design |
Cells were cultured in RPMI1640 medium containing 10% fetal bovine serum (FBS), 100 U/ml penicillin and 100 ug/ml streptomycin. CsA was dissolved in 100% ethanol (vehicle) and treated to cells with 10 mM CsA for 24h
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| Web link |
https://www.spandidos-publications.com/or/50/6/218
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| |
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| Contributor(s) |
Lee D, Chun J, Lee S, Park S, Jeon J |
| Citation(s) |
37888771 |
| |
| Submission date |
Jan 23, 2018 |
| Last update date |
Jan 03, 2024 |
| Contact name |
Ju-Hong Jeon |
| E-mail(s) |
jhjeon2@snu.ac.kr
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| Organization name |
Seoul National University College of Medicine
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| Department |
Department of Physiology and Biomedical Sciences
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| Lab |
Smooth muscle lab
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| Street address |
28 Yongon-Dong, Chongno-Gu
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| City |
Seoul |
| State/province |
Seoul |
| ZIP/Postal code |
110-799 |
| Country |
South Korea |
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| Platforms (1) |
| GPL24532 |
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [CDF: hugene10st_Hs_ENTREZG, Brainarray version 22] |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA431263 |
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