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| Status |
Public on Dec 07, 2020 |
| Title |
The Epigenetic dysregulation of lncRNA on gene expression in Colorectal tumor [RNA-seq] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Our data analysis unveils that differentially expressed long noncoding RNAs and some wrongly transcribed noncoding transcripts have potential DNA binding sites at promoters of differentially expressed or wrongly transcribed coding transcripts, gains and losses of differentially methylated DNA regions also occur at relevant sites, but less specifically. Moreover, both differentially expressed or wrongly transcribed transcripts and gains and losses of differentially methylated DNA regions show significant case-to-case variation.
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| |
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| Overall design |
we applied RNA-seq and MeDIP-seq to 12 colorectal cancer cases with varied differetiation stages and 3 normal colon tissue cases
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| |
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| Contributor(s) |
Zhu H |
| Citation(s) |
33304451 |
|
https://doi.org/10.1016/j.csbj.2020.11.004
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| |
| Submission date |
Jan 15, 2018 |
| Last update date |
Dec 15, 2020 |
| Contact name |
Zhu Hao |
| E-mail(s) |
zhuhao@smu.edu.cn
|
| Phone |
8613533979750
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| Organization name |
Southern Medical University
|
| Street address |
Shatai Road
|
| City |
GuangZhou |
| ZIP/Postal code |
510515 |
| Country |
China |
| |
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| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
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| Samples (15)
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| This SubSeries is part of SuperSeries: |
| GSE109204 |
The Epigenetic dysregulation of lncRNA on gene expression in Colorectal tumor |
|
| Relations |
| BioProject |
PRJNA430130 |
| SRA |
SRP130989 |
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