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| Status |
Public on Jan 01, 2020 |
| Title |
Hyaluronic Acid Synthase-2 (HAS2) overexpression and deficiency effect on hepatic stellate cells |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Analysis of hepatic stellate cells (HSCs) isoltaed from ASMA-HAS2 transgenic and HSC-specific Has2 knockout mice. HAS2 synthesized hyaluronic acid, one of major extracellular matrix. Results provide insight into the role of HAS2 in hepatic stellate cells.
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| |
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| Overall design |
Hepatic stellate cell mRNA profiles of ASMA-HAS2 transgenic (Tg) and Has2 f/f Lrat-cre (KO) mice were generated by deep sequencing, in triplicate, using BGISEQ-500
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| |
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| Contributor(s) |
Yang YM, Deng N, Liu Z, Seki E |
| Citation(s) |
31189722 |
| NIH grant(s) |
| Grant ID |
Grant title |
Affiliation |
Name |
| R01 DK085252 |
Extracellular Matrix Regulates Hepatic Stellate Cell Activation and Fibrosis |
CEDARS-SINAI MEDICAL CENTER |
EKIHIRO SEKI |
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| |
| Submission date |
Dec 28, 2017 |
| Last update date |
Apr 01, 2020 |
| Contact name |
Ekihiro Seki |
| E-mail(s) |
Ekihiro.Seki@cshs.org
|
| Organization name |
Cedars-Sinai Medical Center
|
| Department |
Medicine
|
| Street address |
8700 Beverly Blvd DAVIS, Suite 2029
|
| City |
Los Angeles |
| State/province |
CA |
| ZIP/Postal code |
90036 |
| Country |
USA |
| |
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| Platforms (1) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA427766 |
| SRA |
SRP127652 |
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