|
| Status |
Public on Dec 21, 2017 |
| Title |
ICAMs are not obligatory for functional immune synapses between naïve CD4 T cells and lymph node DCs |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
The quantitative deep bulk MARS-seq analysis demonstrated that DCs from ICAM-1/2 double knockout (DKO) chimeric LNs display similar transcriptomes to those of WT DCs in both their resting and CD40 mAb activated states.
|
| |
|
| Overall design |
Transciptome analysis of activated and resting classical DCs from either WT or ICAM-1/2 DKO chimeric mice was performed. DC cells were isolated from popliteal lymph nodes and sorted according to the following markers: CD45, CD11c and MHC-II
|
| |
|
| Contributor(s) |
Feigelson SW, Curato C, Leshkowitz D, Jung S, Alon R |
| Citation(s) |
29420172 |
| |
| Submission date |
Dec 20, 2017 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Dena Leshkowitz |
| E-mail(s) |
dena.leshkowitz@weizmann.ac.il
|
| Organization name |
Weizmann Institute of Science
|
| Department |
Bioinformatics Unit, Life Sciences Core Facilities
|
| Street address |
P.O.B. 26
|
| City |
Rehovot |
| ZIP/Postal code |
76100 |
| Country |
Israel |
| |
|
| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
|
| Samples (8)
|
|
| Relations |
| BioProject |
PRJNA423233 |
| SRA |
SRP127247 |
Less...
More...