GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE108169 Query DataSets for GSE108169
Status Public on Dec 18, 2017
Title Liver gene expression profiles of catalase knockout mice fed normal and high fat diet
Organism Mus musculus
Experiment type Expression profiling by array
Summary Nonalcoholic fatty liver disease (NAFLD) is the most common type of chronic liver disease. NAFLD is associated with obesity, type 2 diabetes, dyslipidemia, and cardiovascular diseases, and characterized by excessive accumulation of triglycerides in the form of lipid droplets. Liver injury in NAFLD through inflammation and oxidative stress ultimately leads to development of nonalcoholic steatohepatitis and liver cancer. Recently it has been reported that catalase, a major peroxisomal antioxidant, plays a protective role in high-fat diet-induced liver injury. In this study, we further investigated the role of catalase in development of liver disease using transcriptome analysis. Catalase knockout and wild type mice were fed either normal chow or high-fat diet and the gene expression profiles in the liver were compared.
Overall design Total RNA was isolated from livers of wild type or catalase knockout mice fed either normal or high-fat diet for 11 weeks using Trizol method. Agilent’s Mouse Oligo Microarray (44K) was used to examined the gene expression profile. Data was extracted using GeneSpring GX 7.3 (Agilent Technology, USA) and differential expressed genes were compared between groups.
Contributor(s) Ha H, Huh JY, Piao L, Hwang I
Citation missing Has this study been published? Please login to update or notify GEO.
Submission date Dec 17, 2017
Last update date Jan 24, 2018
Contact name Joo Young Huh
Organization name Chonnam National University
Department College of Pharmacy
Street address 77 Yongbong-ro
City Gwangju
ZIP/Postal code 61186
Country South Korea
Platforms (1)
GPL11202 Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version)
Samples (4)
GSM2891639 InVivoLiver_11w_ND
GSM2891640 InVivoLiver_11w_HFD
GSM2891641 InVivoLiver_11w_CKOND
BioProject PRJNA422714

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE108169_RAW.tar 8.7 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap