|
| Status |
Public on Dec 12, 2017 |
| Title |
Genome wide study of microglia in Specific-pathogen-free (SPF) and Germ-free (GF) mice at different stages in males and females (RNA-Seq) |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
RNAseq was performed on microglia from male and female, SPF or GF mice to elucidate the genetic differences implicated by microbiota and gender. DEGs between the various groups gave some ideas on what different pathways or functions might be affected due to the different factors.
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| |
|
| Overall design |
Microglia from SPF and GF mice from embryonic and adult stages of both gender were sorted for sequencing. DEGs were obtained to observe if any signicant genes were affected. Pathway analysis was performed with the set of DEGs.
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| |
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| Contributor(s) |
Low D, Hoeffel G, Ginhoux F |
| Citation(s) |
29275859 |
| |
| Submission date |
Dec 11, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
jinmiao chen |
| E-mail(s) |
chen_jinmiao@immunol.a-star.edu.sg
|
| Organization name |
Singapore Immunology Network
|
| Street address |
8A Biomedical Grove, #04-06 Immunos
|
| City |
Singapore |
| ZIP/Postal code |
138648 |
| Country |
Singapore |
| |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (26)
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| This SubSeries is part of SuperSeries: |
| GSE107130 |
Microbiome influences prenatal and adult microglia in a sex-specific |
|
| Relations |
| BioProject |
PRJNA421946 |
| SRA |
SRP126509 |
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