|
| Status |
Public on Mar 11, 2004 |
| Title |
2.5 mg/kg 2CdA exposure |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
In this time course pregnant CD-1 (outbred) dams were exposed to the 2-chloro analogue of 2'-deoxyadenosine (a metabolic toxin) on 8 d.p.c. The test dose of 2.5 mg/kg 2CdA was modeled for a 5% increased risk of microphthalmia in term fetuses. Sampling intervals were anchored to the conditional biomarker (p53 protein induction) expressed in 2CdA-treated embryos between 3.0- and 4.5h post-exposure. Since p53 protein induction has been defined as a critical event in 2CdA-induced micropthalmia, these sampling intervals represent times before (3.0h), during (4.5h), and after (6.0h) this critical event. All measurements were on RNA from the embryonic headfold.
Keywords = time series
Keywords = 2-chloro-2'-deoxyadenosine
Keywords = embryo
Keywords = p53 protein induction
Keywords = microphthalmia
Keywords: time-course
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| Contributor(s) |
Knudsen TB, Nemeth KR, Singh AV, Charlap JH |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Feb 26, 2004 |
| Last update date |
Mar 02, 2012 |
| Contact name |
Thomas B Knudsen |
| E-mail(s) |
singh.amarv@epamail.epa.gov
|
| Phone |
502-852-4128
|
| Fax |
502-852-4702
|
| URL |
http://systemsanalysis.louisville.edu/
|
| Organization name |
University of Louisville
|
| Department |
Birth Defects Center
|
| Lab |
Systems Analysis Laboratory
|
| Street address |
501 S Preston St
|
| City |
Louisville |
| State/province |
KY |
| ZIP/Postal code |
40202 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL560 |
Developmental Toxicity of the Mouse Embryo (DTME) |
|
| Samples (8)
|
| GSM12066 |
2.5 mg/kg 2CdA headfold at 3.0h |
| GSM12068 |
2.5 mg/kg 2CdA headfold at 3.0h |
| GSM12073 |
2.5 mg/kg 2CdA headfold at 4.5h |
|
| Relations |
| BioProject |
PRJNA87159 |
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