|
| Status |
Public on Feb 13, 2018 |
| Title |
The role of microglia in maturation of adult-born neurons |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Microglia depletion significantly lowered spine density in young (developing) but not mature adult-born-granule-cells (abGCs) in the olfactory bulb. PLX5622 significantly reduces microglia related gene transcripts.
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| |
|
| Overall design |
We tested mouse olfactory bulb transcription in WT mice versus mice treated with a PLX5622 diet (inducing a near-complete microglia depletion).
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| |
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| Contributor(s) |
Rimmerman N, Reshef R, Yirmiya R |
| Citation(s) |
29251592 |
| |
| Submission date |
Nov 14, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Raz Yirmiya |
| Organization name |
Hebrew University of Jerusalem
|
| Street address |
Mount Scopus
|
| City |
Jerusalem |
| ZIP/Postal code |
91905 |
| Country |
Israel |
| |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
|
| Samples (6)
|
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| Relations |
| BioProject |
PRJNA418237 |
| SRA |
SRP124931 |
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