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| Status |
Public on May 09, 2019 |
| Title |
Microarray analysis of liver biopsies at baseline and after one year follow up from 21 patients with histologically proven NASH (responders, bariatric surgery). |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
We used microarray analysis to study the global program of gene expression in the liver of 21 patients with histologically proven NASH who had an improvement in disease activity, including a decrease of lobular inflammation and/or ballooning, one year after Roux-en-Y gastric bypass.
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| Overall design |
High quality RNA appropriate for microarray analysis was isolated from liver biopsies at baseline and after one year follow up.
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| Contributor(s) |
Mogilenko D, Vonghia L, Lefebvre P, Staels B, Francque S, Dombrowicz D |
| Citation |
J.T. Haas, L. Vonghia, D. Mogilenko, A. Verrijken, O. Molendi-Coste, S. Fleury, A. Deprince, A. Nikitin, E. Woitrain, L. Ducrocq-Geoffrey, S. Pic, B. Derudas, H. Dehondt, C. Gheeraert, L. Van Gaal, A. Driessen, P. Lefebvre, B. Staels, S. Francque, D.D. Dombrowicz. Transcriptional network analysis implicates altered hepatic immune function in NASH development and resolution. Nature Metabolism volume 1, pages 604-614 (2019). https://www.nature.com/articles/s42255-019-0076-1
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| Submission date |
Nov 09, 2017 |
| Last update date |
Aug 08, 2019 |
| Contact name |
Lefebvre Philippe |
| Organization name |
Inserm
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| Lab |
JK
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| Street address |
Bld Pr Jules Leclerc
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| City |
Lille |
| ZIP/Postal code |
59000 |
| Country |
France |
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| Platforms (1) |
| GPL16686 |
[HuGene-2_0-st] Affymetrix Human Gene 2.0 ST Array [transcript (gene) version] |
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| Samples (111)
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| Relations |
| BioProject |
PRJNA417952 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE106737_RAW.tar |
814.5 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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