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| Status |
Public on Jan 06, 2020 |
| Title |
Enhanced interferon response genes in bronchial epithelial cells after in vivo rhinovirus challenge of asthma patients |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
In asthma there are exaggerated rather than impaired innate and adaptive interferon responses in vivo after RV16 infection, which strongly correlate with inflammation and loss of asthma control.
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| |
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| Overall design |
Mild asthma patients (n=15) and healthy controls (n=4) were challenged with RV16. PBECs were obtained by bronchial brushes before and 6 days after RV16. The transcriptome was determined by RNAseq and also correlated with clinical outcomes.
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| |
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| Contributor(s) |
Ravi A, Lutter R, Koster J |
| Citation missing |
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| |
| Submission date |
Oct 31, 2017 |
| Last update date |
Jan 07, 2020 |
| Contact name |
Richard Volckmann |
| E-mail(s) |
r.volckmann@amsterdamumc.nl
|
| Organization name |
Academic Medical Centre, University of Amsterdam
|
| Department |
Department of Oncogenomics
|
| Street address |
P.O. Box 22700
|
| City |
Amsterdam |
| ZIP/Postal code |
1100DE |
| Country |
Netherlands |
| |
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| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
|
| Samples (38)
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|
| Relations |
| BioProject |
PRJNA416665 |
| SRA |
SRP123237 |
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