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Series GSE105447 Query DataSets for GSE105447
Status Public on Feb 01, 2018
Title A Brain Penetrant Mutant IDH1 Inhibitor Provides In Vivo Survival Benefit
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary We profiled two IDH1 mutant glioma models, grown as intracranial xenografts, treated with an IDH1 inhbitor. One model, BT424, was responsive to IDH1 inhibition by compound treatement and also displayed more transcriptional changes in response to treatment. The other model, GB10, was not responsive to IDH1 inhibition and was transcriptionally quiet after treatment with compound.
 
Overall design BT142 or GB10 xenograft bearing animals were treated with 30 mpk MRK-A or vehicle for 4 weeks
 
Contributor(s) Levitan D
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Submission date Oct 20, 2017
Last update date May 15, 2019
Contact name Diane Levitan
E-mail(s) diane.levitan@merck.com
Phone 908-740-3718
Organization name Merck
Department Translational Medicine
Street address 2015 Galloping Hill Road
City Kenilworth
State/province NJ
ZIP/Postal code 07033
Country USA
 
Platforms (1)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
Samples (18)
GSM2826104 DS-96009_PID21071_IDH1_RNA-Seq_17Jun2015.Human
GSM2826105 DS-96028_PID21071_IDH1_RNA-Seq_17Jun2015.Human
GSM2826106 DS-96032_PID21071_IDH1_RNA-Seq_17Jun2015.Human
Relations
BioProject PRJNA415191
SRA SRP120609

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE105447_Human.Genes.FPKM.UQNorm.Log2.xlsx 4.4 Mb (ftp)(http) XLSX
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record
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