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| Status |
Public on Jun 29, 2018 |
| Title |
H.pylori infections induces a transcriptional signature in gastric eosinophils, as determined by RNA sequencing |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Eosinophils are highly abundant throughout the gastrointestinal tract. However, their function in bacterially-induced gastrointestinal inflammatory disorders is poorly understood. In this study, we have examined the function and regulation of gastric eosinophils in the steady state and during infection with Helicobacter pylori. We find that eosinophils are recruited to sites of infection, make direct contact with live bacteria, and activate a signature transcriptional program.
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| Overall design |
SiglecF+ CD11b+ MHCII- gastric eosinophils were sorted by flow cytometry from the gastric lamina propria of individual H. pylori-infected B6 mice or uninfected controls and compared for their gene expression profile.
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| Contributor(s) |
Arnold IC, Muller A |
| Citation(s) |
29970473 |
| |
| Submission date |
Oct 18, 2017 |
| Last update date |
Jul 25, 2021 |
| Contact name |
Hubert Rehrauer |
| E-mail(s) |
Hubert.Rehrauer@fgcz.ethz.ch
|
| Organization name |
ETH Zurich / University of Zurich
|
| Department |
FGCZ
|
| Street address |
Winterthurerstr. 190
|
| City |
Zurich |
| ZIP/Postal code |
8057 |
| Country |
Switzerland |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (15)
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| Relations |
| BioProject |
PRJNA414920 |
| SRA |
SRP120384 |
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