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| Status |
Public on Nov 02, 2017 |
| Title |
IL-1R8 is a checkpoint in NK cells regulating anti-tumor and anti-viral activity |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We reported that IL-1R8 serves as a checkpoint for NK cell maturation and effector functions. Its genetic blockade unleashes NK-cell mediated resistance to hepatic carcinogenesis, hematogenous liver and lung metastasis and cytomegalovirus infection.
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| |
|
| Overall design |
RNA profile from splenic NK cells isolated by FACS sorting from wild-type and Il1r8-/- mice. NK cells were stimulated or not with murine IL-18 (20 ng/ml) for 4 hrs.
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| |
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| Contributor(s) |
Bonavita E, Molgora M, Mantovani A, Garlanda C |
| Citation(s) |
29072292 |
| |
| Submission date |
Oct 16, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Santiago Zelenay |
| E-mail(s) |
santiago.zelenay@cruk.manchester.ac.uk
|
| Organization name |
CRUK Manchester Institute
|
| Lab |
Cancer Inflammation and Immunity
|
| Street address |
Alderley Park
|
| City |
Manchester |
| State/province |
UK |
| ZIP/Postal code |
SK10 4TG |
| Country |
United Kingdom |
| |
|
| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
|
| Samples (12)
|
|
| Relations |
| BioProject |
PRJNA416792 |
| SRA |
SRP123345 |
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