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| Status |
Public on May 01, 2018 |
| Title |
Diet-Induced Obesity Leads to Infarct Expansion, increased neuroinflammation, and Worsened Outcomes after Stroke |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We used RNA-seq to show that high-fat-diet-fed mice have a larger neuroinflammatory response following stroke. Elucidating these mechanisms may lead to the development of treatments that will benefit people with obesity who suffer from a stroke.
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| Overall design |
145 C57BL/6J mice were either fed a 60% kCal fat diet or 6% kCal fat diet for 6 or 15 weeks. Focal ischemia was induced and brain tissue was harvested for RNA-seq.
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| Contributor(s) |
Piening B, Peterson T, Buckwalter M |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Oct 12, 2017 |
| Last update date |
Jul 25, 2021 |
| Contact name |
Brian D Piening |
| E-mail(s) |
bpiening@stanford.edu
|
| Organization name |
Stanford
|
| Department |
Genetics
|
| Lab |
Snyder
|
| Street address |
300 Pasteur Drive
|
| City |
Palo Alto |
| State/province |
CA |
| ZIP/Postal code |
94304 |
| Country |
USA |
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| Platforms (1) |
| GPL21103 |
Illumina HiSeq 4000 (Mus musculus) |
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| Samples (26)
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| Relations |
| BioProject |
PRJNA414079 |
| SRA |
SRP119845 |
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