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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Sep 20, 2018 |
| Title |
Protein kinase D1 deletion in adipocytes enhances energy dissipation and protects against adiposity |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
DAG-activated Pkd1 promotes triglyceride accumulation in adipocytes; Pkd1 promotes lipogenesis and suppresses mitochondrial function in adipocytes in an AMPK-dependent manner; Pkd1 suppresses expression of genes characteristic for beige adipocytes; Deletion of Pkd1 in adipocytes protects mice from diet-induced obesity, T2D and liver steatosis.
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| Overall design |
Gene expression changes in subcutaneous adipose tissue of mice after deletion of Pkd1.
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| Contributor(s) |
Löffler M, Mayer AE, Trujillo J, Ade CP, Karwen T, Janaki-Raman S, Slotta A, El-Merahbi R, Loza Valdes A, Erk M, Matesanz N, Torres JL, Marcos M, Sabio G, Schulze A, Eilers M, Sumara G |
| Citation(s) |
30389661 |
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| Submission date |
Oct 10, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Martin Eilers |
| Organization name |
University of Wuerzburg
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| Department |
Chair for Biochemistry and Molecular Biology
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| Lab |
Martin Eilers
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| Street address |
Am Hubland
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| City |
Wuerzburg |
| ZIP/Postal code |
97074 |
| Country |
Germany |
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| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA413844 |
| SRA |
SRP119707 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE104797_Pkd1_KO_vs_WT.csv.gz |
816.4 Kb |
(ftp)(http) |
CSV |
| GSE104797_rawcount_matrix_all_AP1_samples.csv.gz |
691.7 Kb |
(ftp)(http) |
CSV |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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